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“Health” including “Healthy body”, “Healthy
environment” and “Healthy life” is the theme of teaching and doing research and/or
extension pursued by all faculty members in the College of Life Sciences, NCYU.
Basic researches and innovative applications in a broadest spectrum of phyto-
and microbial chemicals have been intensively conducted. Respective research
interests and approaches conducted by each principal investigator are outlined
and collaborations are definitely welcomed for further contact. |
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Screening Technique Innovation of Drug and
Nutraceutical through Construction of in-vitro and in-vivo
Models. Interests cover exploration of the potential raw material including
agricultural products, such as peanut, soybeans, mulberry and grapes, native
Chinese herbs, and edible mushrooms. Bio-medicinal and nutraceutical activities
include antioxidative potency, free radical scavenging, reactive oxygen
elimination, enhancement of immune surveillance, anti-inflammation, anti-tumor
proliferation and formation, anti-cancer metastasis, prevention of
cardiovascular diseases, probiotics of lactic acid bacteria and immunity
enhancement through tests of chemical reactions, various cell lines and animal
models. The targeted bioactive compounds include resveratrol and derivatives extracted
from peanuts, ß-glucan extracted from diversified mushrooms and hydroquinone
compounds extracted from lacquer trees. (Further contact: Dr. J. G. Tsay; jgtsay@mail.ncyu.edu.tw).
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Functional foods
development in use of various nutraceuticals originated from agricultural
products, traditional Chinese herbs and various edible mushrooms. Development
of traditional oriental fermented foods and beverages. Nutraceutical activity
evaluation of the functional foods by animal test. (Further contact: Dr. C. Y.
Tseng; cytseng@mail.ncyu.edu.tw).
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Screening, bioassay and potential use of
the bioactive substances extracted from soybeans and peanuts. Extraction,
purification and identification of antioxidants, tyrosinase inhibitors from
edible mushrooms and germinating peanut sprouts. Bio-transformation of
isoflavones of the domestically grown non-GMO soybeans to enrich isoflavone
bioactivity and development of the dietary supplements and functional foods for
health benefit. Investigation of isoflavone metabolism in formation of equol as
a risk index of cancer incidence. Enhancement of resveratrol biosynthesis by
peanut germination along with preparation of peanut sprouts. (Further contact:
Dr. R. Y.-Y. Chiou; rychiou@mail.ncyu.edu.tw).
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Dietary nutrients and potential feed
ingredients for the growth, antioxidation, and immunity improvements of aquatic
animals and their application in nutritional quality enhancement and shelf-life
extension of the seafood products; chuhuang@mail.ncyu.edu.tw).
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Research
interest focused on
Ecological Restoration.
In particular collaborated with Institute for Sustainable
Environment, University of Oregon,
through
the incorporation the same research techniques, it can be applied to the
restoration of the OuKao wetland prairie and Alisan mountain. (Further contact: Dr. W. F. Hsiao; wfhsiao@mail.ncyu.edu.tw).
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Modification, scale-up production by E. coli, insect or mammal cells and
purification of recombinant proteins. Bioactive analyses including
cytotoxicity, cell proliferation, differentiation and signal transduction of
the plant, herbal and synthetic compounds. (Further contact: Dr. J. G. Su; jgjsu@mail.ncyu.edu.tw).
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Microbial production of bioactive compounds
including antibiotics, nutraceuticals and probiotics by fermentation.
Biotechnology innovation and optimization of bio-reactor operation in efficient
production of targeted compounds. Bio-transformation of bio-products. (Further
contact: Dr. C. W. Hsieh; cwhsieh@mail.ncyu.edu.tw).
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Purification and bioactivity evaluation of
polyphenols (including coumarins, flavonoids, ellagitanins, anthraquinones, and
lignans). GC-MS, HPLC-DAD-ELSD and HPLC-MS quantitative analysis of Traditional
Chinese Medicines (TCMs), herbs and natural products. Determination the purine
contents in food and dietary materials. Isolation and screening of
anti-microbial, whiting, anti-cancer and anti-inflammatory natural products.
(Further contact: Dr. L. G. Chen; lgchen@mail.ncyu.edu.tw).
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Pharmacological and cellular and molecular
biology in relation to inflammation in mammalian cells. Study focus on cellular
signal transduction and regulation of gene expression. Innovative screening
technique for drug screening against inflammation, cancer and liver fibrosis.
(Further contact: Dr. Y. W. Liu; ywlss@mail.ncyu.edu.tw).
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Investigations of lymphocyte blastogenesis,
mixed lymphocyte reaction, mechanism of macrophage phagocytosis and evaluation
of oxidative burst oxygen dependent radicals. Physiological balance of immunity
and immune regulation of food and drug constituents. (Further contact: Dr.
Brian Weng; brain@mail.ncyu.edu.tw).
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Investigation of the effect of microalgae on immune responses of hard clam, the reproduction and tolerance of the
invased freshwater
animals, physiological effects of acid environment on the giant freshwater
prawn and data base construction of algae. (Further contact: Dr. S. M. Chen; smchen@mail.ncyu.edu.tw)
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The innate immunity and viral
infection. We have previously shown that higher serum levels for all three b-chemokines,
were found in nine Taiwanese who had histories of multiple sexual exposures to
HIV remained uninfected, suggesting that b-chemokines are the major protective
factors. Besides this, characteristic of this cohort is that polymorphonuclear
cells isolated from these individuals’ bloods all consisted of the higher
percentages of lower-buoyant-density neutrophils, which could be co-purified
with PBMC by Ficoll-Paque centrifugation. Since many recent reports have
demonstrated that these a-defensin-1, -2, and –3 possessed anti-HIV capability,
therefore, we
strongly believe that a-defensins in neutrophils, like b-chemokines, also play
an important role in protecting the HIV-uninfected cohort from the infection of
the virus.
We are interest to
gain insight of the mechanism concerning innate immunity against viral
pathogens, including HIV. The project will employ both cell and molecular
biology methods including microarray genomic and proteomic tools.
(Further contact: Dr. Li Ching; chingli@mail.ncyu.edu.tw).
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Basidiomycetes produce a large number of
secondary metabolites which show antibacterial, antifungal, antiviral,
cytotoxic and hallucinogenic activity or which can be a source of plant growth
regulators or flavours. A current interest has been focused on screening and
isolation of antibacterial and antifungal compounds from basidiomycete sources.
(Further contact: Dr. J. G. Tsay; jgtsay@mail.ncyu.edu.tw).
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Research interest
major in residues some chemicals in aquatic environments. Chemicals include antibiotics
and disinfectants that applied by human manuscriptions or pollutants in aquatic
environments. We concern about the environmental fates, distributions, extents
to decline, residues and possible toxicities to aquatic biota. The antibiotics
evaluated include oxytetracylcine, chloramphenicol, thiamphenicol, florfenicol
and oxolinic acid and flumequine, etc. The disinfectants include some sulfa
agents. The chemical pollutants include chlorophenols and PAHs (polycyclic
aromatic hydrocarbons). Another track of research is focus on
interaction of aquatic animal populations and environment factors. The
environment factors include water and sediment qualities, and disturbances of
invaded species. （Further
contact: Dr. H.T. Lai; htlai@mail.ncyu.edu.tw）
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Responses of stresses in teleosts: an
interactive response among the endocrine, energy cost, immuno-system, free
radical and metallothionein expression. The present studies almost focus on the
stress responses of fish followed heavy metals exposure, especially the
functions and regulative mechanism of metallothionein in fish upon heavy metal
induction.（Further contact: Dr.
S. M. Wu;
sumei@mail.ncyu.edu.tw ）
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